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BMRs
BMRs are not the whole story relating weight and thyroid. For example, when metabolic rate
s are reduced in animals by various means, these animals often do not show the expected excess weight gain. Thus, the relationship between metabolic rates, energy balance, and weight changes is very complex. There are many other hormones, proteins, and other chemicals that are very important for controlling energy expenditure, food intake, and body weight.
It has been appreciated for a very long time that there is a complex relationship between thyroid disease, body weight and metabolism. Thyroid hormone regulates metabolism in both animals and humans. Metabolism is determined by measuring the amount of oxygen used by the body over a specific amount o
Indeed, measurement of the BMR was one of the earliest tests used to assess a patient's thyroid status. Patients whose thyroid glands were not working were found to have low BMRs, and those with overactive thyroid glands had high BMRs. Later studies linked these observations with measurements of thyroid hormone levels and showed that low thyroid hormone levels were associated with low BMRs and high thyroid hormone levels were associated with BMRs.

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Differences in BMRs are associated with changes in energy balance. Energy balance reflects the difference between the amount of calories one eats and the amount of calories the body uses. If a high BMR is induced by the administration of drugs, such as amphetamines, animals often have a negative energy balance which leads to weight loss.
 
 
 
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